Mitochondrial Metabolism, Dysfunctions in Senescence Cell and the Possible Interventions through Herbal Medicines

The mitochondria are the cell`s powerhouse. They considered ubiquitous organelles of all eukaryotic cells, being responsible for cell’s life and death cycle. Through stimuli in environment which they live, can modulate their own biogenesis as well signal retrograde to nucleus modify structure proteins. Since mitochondrial genome contains only 37 genes, much encoding its proteins depends on nuclear genome. Thus, communication between seems be a target science understanding pathologies associated with this organelle. Some medicinal herbs have been shown influence biogenesis, such Gynostemma pentaphyllun (GP) berberine, increase phosphorylation AMPactivated protein kinase (AMPK). Just GP berberine phosphorylate AMPK signaling sesquiterpene beta-caryophyllene (BCP) demonstrated positive results reorganizing transcription factors, an agonist peroxisome proliferatoractivated alpha receptor (PPAR-α). Another plant derivative, non-psychoactive cannabinoid known cannabidiol (CBD), has showing control metabolism calcium matrix. In review, we seek get closer look at biochemical mechanisms action some these plants, synergies different treatments. view oriental medicines, use always part treatment protocols. However, effectiveness treatments relation synergy observed future clinical trials better understanding.